{"ticker": "RPHM", "overview": {"cik": "1637715", "ticker": "OKUR", "name": "OnKure Therapeutics, Inc.", "industry": "Pharmaceutical Preparations", "country": "United States", "sic": "2834", "announcements": [{"form": "SCHEDULE 13G/A", "date": "2026-08-14", "title": "Form SCHEDULE 13G/A", "accession": "0001104659-26-097335", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-08-14", "title": "Form SCHEDULE 13G/A", "accession": "0000921895-26-002177", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-08-14", "title": "Form SCHEDULE 13G/A", "accession": "0001493152-26-038382", "price_sensitive": false}, {"form": "4/A", "date": "2026-08-13", "title": "Form 4/A", "accession": "0001622769-26-000006", "price_sensitive": false}, {"form": "8-K", "date": "2026-08-13", "title": "Material event", "accession": "0001193125-26-347315", "price_sensitive": true}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001193125-26-344874", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001547100-26-000005", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001921956-26-000003", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001622769-26-000002", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001889716-26-000002", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001240122-26-000006", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001644467-26-000002", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001609284-26-000004", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001692747-26-000004", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0002037442-26-000002", "price_sensitive": false}, {"form": "4", "date": "2026-08-11", "title": "Insider transaction", "accession": "0001748961-26-000002", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-08-10", "title": "Form SCHEDULE 13G/A", "accession": "0001617201-26-000003", "price_sensitive": false}, {"form": "424B5", "date": "2026-08-04", "title": "Prospectus", "accession": "0001193125-26-332839", "price_sensitive": false}, {"form": "8-K", "date": "2026-08-04", "title": "Material event", "accession": "0001193125-26-332809", "price_sensitive": true}, {"form": "10-Q", "date": "2026-08-04", "title": "Quarterly report", "accession": "0001193125-26-332773", "price_sensitive": true}, {"form": "4", "date": "2026-06-24", "title": "Insider transaction", "accession": "0001609284-26-000003", "price_sensitive": false}, {"form": "4", "date": "2026-06-24", "title": "Insider transaction", "accession": "0001692747-26-000003", "price_sensitive": false}, {"form": "4", "date": "2026-06-08", "title": "Insider transaction", "accession": "0001193125-26-262279", "price_sensitive": false}, {"form": "4", "date": "2026-06-08", "title": "Insider transaction", "accession": "0001547100-26-000004", "price_sensitive": false}, {"form": "4", "date": "2026-06-08", "title": "Insider transaction", "accession": "0001921956-26-000002", "price_sensitive": false}]}, "description": "RPHM trades as RPHM. Privy Trades holds 66 insider filings for the company, from April 2021 to September 2024. Across those, 11 insiders disclosed 23 open-market purchases totalling $33.80M against 3 sales totalling $1.76M. The most recent filing on record is dated 25 September 2024.", "exchange": null, "stats": {"buy_n": 23, "buy_sum": 33796444.5942, "sell_n": 3, "sell_sum": 1757553.8125, "net": 32038890.7817, "insiders": 11, "first_date": "2021-04-09", "last_date": "2024-09-25"}, "metrics": {"ticker": "RPHM", "has_prices": false}, "trades": [{"id": "0001373604-24-000098", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Braden Michael Leonard", "who_key": "Leonard Braden Michael", "role": "10% Owner", "person_type": "TEN_PCT", "person_label": "10% Owners", "action": "BUY", "amount": 144737.7544, "score": 38.8, "price_sensitive": true, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Big holder adds $145K of RPHM", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000137360424000098/0001373604-24-000098-index.htm", "trade_date": "2024-09-25", "timestamp": "2024-09-25", "mins": 1106869}, {"id": "0001373604-24-000094", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Braden Michael Leonard", "who_key": "Leonard Braden Michael", "role": "10% Owner", "person_type": "TEN_PCT", "person_label": "10% Owners", "action": "BUY", "amount": 76236.86, "score": 35.4, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "RPHM's biggest backer adds $76K", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000137360424000094/0001373604-24-000094-index.htm", "trade_date": "2024-09-18", "timestamp": "2024-09-18", "mins": 1116949}, {"id": "0001373604-24-000090", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Braden Michael Leonard", "who_key": "Leonard Braden Michael", "role": "10% Owner", "person_type": "TEN_PCT", "person_label": "10% Owners", "action": "BUY", "amount": 484344.088, "score": 45.6, "price_sensitive": true, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "10% owner buys $484K more of RPHM", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000137360424000090/0001373604-24-000090-index.htm", "trade_date": "2024-09-16", "timestamp": "2024-09-16", "mins": 1119829}, {"id": "0001373604-24-000071", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Braden Michael Leonard", "who_key": "Leonard Braden Michael", "role": "10% Owner", "person_type": "TEN_PCT", "person_label": "10% Owners", "action": "BUY", "amount": 380597.7859, "score": 44.4, "price_sensitive": true, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Big holder adds $381K of RPHM", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000137360424000071/0001373604-24-000071-index.htm", "trade_date": "2024-08-14", "timestamp": "2024-08-14", "mins": 1167349}, {"id": "0001373604-24-000028", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Braden Michael Leonard", "who_key": "Leonard Braden Michael", "role": "10% Owner", "person_type": "TEN_PCT", "person_label": "10% Owners", "action": "BUY", "amount": 639578.36, "score": 48.3, "price_sensitive": true, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Major holder piles $640K into RPHM", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000137360424000028/0001373604-24-000028-index.htm", "trade_date": "2024-05-14", "timestamp": "2024-05-14", "mins": 1299829}, {"id": "0001209191-23-047626", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Ashley Hall", "who_key": "Hall Ashley", "role": "Chief Development Officer", "person_type": "C_SUITE", "person_label": "C-Suite", "action": "SELL", "amount": 98057.8125, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Top exec sells $98K of RPHM", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123047626/0001209191-23-047626-index.htm", "trade_date": "2023-08-28", "timestamp": "2023-08-28", "mins": 1674229}, {"id": "0001209191-23-043558", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Michael G. Grey", "who_key": "GREY MICHAEL G", "role": "Executive Chairman, Director", "person_type": "EXEC", "person_label": "Execs", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123043558/0001209191-23-043558-index.htm", "trade_date": "2023-07-26", "timestamp": "2023-07-26", "mins": 1721749}, {"id": "0001209191-23-039541", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Novo Holdings A/S", "who_key": "Novo Holdings A/S", "role": "10% Owner", "person_type": "TEN_PCT", "person_label": "10% Owners", "action": "SELL", "amount": 709740.0, "score": 0.0, "price_sensitive": true, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "10% owner sells $710K of RPHM", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123039541/0001209191-23-039541-index.htm", "trade_date": "2023-06-23", "timestamp": "2023-06-23", "mins": 1769269}, {"id": "0001209191-23-035557", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Eric M. Dube", "who_key": "Dube Eric M", "role": "Director", "person_type": "BOARD", "person_label": "Board", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035557/0001209191-23-035557-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035560", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Stacey Denenberg Seltzer", "who_key": "Seltzer Stacey Denenberg", "role": "Director", "person_type": "BOARD", "person_label": "Board", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035560/0001209191-23-035560-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035562", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Niall O'Donnell", "who_key": "O'Donnell Niall", "role": "Director", "person_type": "BOARD", "person_label": "Board", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035562/0001209191-23-035562-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035563", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Bali Muralidhar", "who_key": "Muralidhar Bali", "role": "Director", "person_type": "BOARD", "person_label": "Board", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035563/0001209191-23-035563-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035564", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Paul W. Hoelscher", "who_key": "Hoelscher Paul W.", "role": "Director", "person_type": "BOARD", "person_label": "Board", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035564/0001209191-23-035564-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035565", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Michael G. Grey", "who_key": "GREY MICHAEL G", "role": "Executive Chairman, Director", "person_type": "EXEC", "person_label": "Execs", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035565/0001209191-23-035565-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035566", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Roshawn A. Blunt", "who_key": "Blunt Roshawn A.", "role": "Director", "person_type": "BOARD", "person_label": "Board", "action": "NON-SIGNAL", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "Director files routine paperwork on RPHM \u2014 no open-market trade", "source_url": "https://www.sec.gov/Archives/edgar/data/1637715/000120919123035566/0001209191-23-035566-index.htm", "trade_date": "2023-06-06", "timestamp": "2023-06-06", "mins": 1793749}, {"id": "0001209191-23-035585", "src": "INSIDERS", "ticker": "RPHM", "cik": "1637715", "company": "OnKure Therapeutics, Inc.", "company_raw": "Reneo Pharmaceuticals, Inc.", "who": "Edward T. 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