{"ticker": "KPTI", "overview": {"cik": "1503802", "ticker": "KPTI", "name": "Karyopharm Therapeutics Inc.", "industry": "Pharmaceutical Preparations", "country": "United States", "sic": "2834", "announcements": [{"form": "4", "date": "2026-10-19", "title": "Insider transaction", "accession": "0001193125-26-425227", "price_sensitive": false}, {"form": "8-K", "date": "2026-10-14", "title": "Material event", "accession": "0001193125-26-421025", "price_sensitive": true}, {"form": "SCHEDULE 13G/A", "date": "2026-10-08", "title": "Form SCHEDULE 13G/A", "accession": "0001636587-26-000086", "price_sensitive": false}, {"form": "4", "date": "2026-10-02", "title": "Insider transaction", "accession": "0001193125-26-412209", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-09-25", "title": "Form SCHEDULE 13G/A", "accession": "0001636587-26-000084", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-09-25", "title": "Form SCHEDULE 13G/A", "accession": "0001636587-26-000083", "price_sensitive": false}, {"form": "8-K", "date": "2026-09-18", "title": "Material event", "accession": "0001193125-26-395517", "price_sensitive": true}, {"form": "8-K", "date": "2026-09-11", "title": "Material event", "accession": "0001193125-26-388621", "price_sensitive": true}, {"form": "SCHEDULE 13G", "date": "2026-09-04", "title": "Form SCHEDULE 13G", "accession": "0001104659-26-105556", "price_sensitive": false}, {"form": "4", "date": "2026-09-02", "title": "Insider transaction", "accession": "0001193125-26-380404", "price_sensitive": false}, {"form": "8-K", "date": "2026-08-31", "title": "Material event", "accession": "0001193125-26-375495", "price_sensitive": true}, {"form": "SCHEDULE 13G/A", "date": "2026-08-14", "title": "Form SCHEDULE 13G/A", "accession": "0001231919-26-000925", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-08-14", "title": "Form SCHEDULE 13G/A", "accession": "0001831942-26-000037", "price_sensitive": false}, {"form": "10-Q", "date": "2026-08-13", "title": "Quarterly report", "accession": "0001193125-26-347906", "price_sensitive": true}, {"form": "8-K", "date": "2026-08-13", "title": "Material event", "accession": "0001193125-26-347897", "price_sensitive": true}, {"form": "SCHEDULE 13G/A", "date": "2026-08-12", "title": "Form SCHEDULE 13G/A", "accession": "0000919574-26-004964", "price_sensitive": false}, {"form": "SCHEDULE 13G/A", "date": "2026-08-11", "title": "Form SCHEDULE 13G/A", "accession": "0000886982-26-000401", "price_sensitive": false}, {"form": "8-K", "date": "2026-07-31", "title": "Material event", "accession": "0001193125-26-326995", "price_sensitive": true}, {"form": "4", "date": "2026-07-30", "title": "Insider transaction", "accession": "0001193125-26-326290", "price_sensitive": false}, {"form": "SCHEDULE 13G", "date": "2026-07-28", "title": "Form SCHEDULE 13G", "accession": "0002012383-26-002546", "price_sensitive": false}, {"form": "8-K", "date": "2026-07-17", "title": "Material event", "accession": "0001193125-26-307964", "price_sensitive": true}, {"form": "SCHEDULE 13G/A", "date": "2026-06-05", "title": "Form SCHEDULE 13G/A", "accession": "0001897612-26-000511", "price_sensitive": false}, {"form": "8-K", "date": "2026-05-28", "title": "Material event", "accession": "0001503802-26-000027", "price_sensitive": true}, {"form": "S-8", "date": "2026-05-27", "title": "Employee share plan", "accession": "0001193125-26-242089", "price_sensitive": false}, {"form": "S-8", "date": "2026-05-27", "title": "Employee share plan", "accession": "0001193125-26-242083", "price_sensitive": false}]}, "description": "Karyopharm Therapeutics Inc. trades as KPTI on the NASDAQ and is registered in the United States, classified under Pharmaceutical Preparations (SIC 2834). Privy Trades holds 573 insider filings for the company, from November 2013 to October 2026. Across those, 25 insiders disclosed 14 open-market purchases totalling $10.31M against 324 sales totalling $143.97M. The most recent filing on record is dated 28 October 2026.", "exchange": "NASDAQ", "stats": {"buy_n": 14, "buy_sum": 10312155.385400001, "sell_n": 324, "sell_sum": 143968368.4193, "net": -133656213.0339, "insiders": 25, "first_date": "2013-11-12", "last_date": "2026-10-16"}, "metrics": {"ticker": "KPTI", "has_prices": true, "as_of": "2026-08-07", "last": 2.12, "prev_close": 1.95, "change": 0.17000000000000015, "change_pct": 0.08717948717948726, "session_volume": 1792750.0, "vwap_5": 1.9747282022671135, "vwap_20": 3.447754104119152, "vwap_60": 5.146115581098259, "vwap_250": 6.1960445631944, "high_52w": 10.67, "low_52w": 1.91, "avg_volume_20": 2466917.9, "sessions": 400, "market_cap": null}, "trades": [{"id": "13DG-0001104659-26-119710", "src": "13DG", "ticker": "KPTI", "cik": "1503802", "company": "Karyopharm Therapeutics Inc.", "company_raw": "Karyopharm Therapeutics Inc.", "who": "Integrated CORE Strategies (US) LLC", "who_key": "INTEGRATED CORE STRATEGIES (US) LLC", "role": "Substantial holder \u00b7 13G/A", "person_type": "WHALE", "person_label": "Whales", "action": "DISCLOSURE", "amount": 0.0, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "INTEGRATED CORE STRATEGIES (US) LLC moves to a 0.2% passive stake in KPTI", "source_url": "https://www.sec.gov/Archives/edgar/data/1319244/0001104659-26-119710-index.htm", "trade_date": "2026-10-28", "timestamp": "2026-10-28", "mins": 8088}, {"id": "0001193125-26-425227", "src": "INSIDERS", "ticker": "KPTI", "cik": "1503802", "company": "Karyopharm Therapeutics Inc.", "company_raw": "Karyopharm Therapeutics Inc.", "who": "Kristin Abate", "who_key": "Abate Kristin", "role": "Chief Accounting Officer", "person_type": "C_SUITE", "person_label": "C-Suite", "action": "SELL", "amount": 1647.072, "score": 0.0, "price_sensitive": false, "cluster": 0, "industry": "Pharmaceutical Preparations", "country": "United States", "headline": "An exit at the top? 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